Abstract Search

ea0032p603 | Female reproduction | ECE2013

PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenemia

Mastorakos George , Paltoglou George , Tavernarakis George , Christopoulos Panagiotis , Vlassi Margarita , Gazouli Maria , Deligeoroglou Efthimios , Creatsas George

Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.Design: Casecontrol genetic association study.Patients: PCOS cases (NIH criteria) and 112 controls.Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.16...

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ea0044p211 | Reproduction | SFEBES2016

Insight into the molecular mechanisms underlying alterations in gonadotropin receptor activity in polycystic ovarian syndrome

Owens Lisa , Lerner Avi , Sposini Silvia , Christopoulos George , Khanjani Shiran , Islam Razia , Lavery Stuart , Tsui Vicky , Hardy Kate , Franks Stephen , Hanyaloglu Aylin

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 510% of women of reproductive age, and is the major cause of anovulatory infertility. Aberrant secretion and/or action of gonadotropins are implicated but, to date, we have only limited knowledge about the precise mechanisms involved. Recent genome wide association studies have discovered signals at loci close to the genes coding for gonadotropin receptors. The functional significanc...

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Endocrine Abstracts

PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenemia

Insight into the molecular mechanisms underlying alterations in gonadotropin receptor activity in polycystic ovarian syndrome

BiosciAbstracts